Genetics of Insomnia
نویسندگان
چکیده
Despite insomnia being the most common sleep disorder, little is known about the contribution of genetics to its etiology and pathophysiology. Between 6% and 10% of individuals experience insomnia that is chronic in nature, whereas another 25% report occasional difficulties with sleep. Insomnia is also associated with several negative sequelae including fatigue, irritability, and impaired concentration and memory. Longitudinal studies have also repeatedly shown that insomnia is a risk factor for the development of new-onset mood, anxiety, and substance-use disorders. Given the prevalence of insomnia and its associated public health impact, advances in our understanding of the genetic underpinnings of the disorder could lead to prevention and treatment efforts that would benefit a substantial proportion of the population. The goal of this review is to provide an overview of the current literature on the genetics of insomnia and to propose a research agenda for future studies.
منابع مشابه
Genetic Pathways to Insomnia
This review summarizes current research on the genetics of insomnia, as genetic contributions are thought to be important for insomnia etiology. We begin by providing an overview of genetic methods (both quantitative and measured gene), followed by a discussion of the insomnia genetics literature with regard to each of the following common methodologies: twin and family studies, candidate gene ...
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